Parkinson's Cure Journey

Growth factors

The lane

Status
Revived. Set aside, then taken up again after new evidence.
Verdict
GDNF infusions, neurturin gene therapy and fosgonimeton failed; AB-1005 (REGENERATE-PD, readout ~2028) and CDNF keep it alive.
Family
Restoration
Landmarks
11 in this lane, 2 more tagged with it. Advanced 2 · Open 4 · Pending 1 · Superseded 1 · Dead end 3

The verdict and status come from the project's branches.yaml and use research wording.

Landmarks in this lane

11 landmarks drawn in this lane, oldest first. Select a column heading to sort.
GDNF discovered1993DiscoveryConfirmed and built on––19 Oct 20263
GDNF: the growth-factor idea, from infusions to gene therapy2003–2026DiscoveryStill being studied––19 Oct 20264
GDNF infusion trials (Amgen, Bristol)2006–2019Trial in peopleDid not work26919 Oct 20263
CERE-120 (AAV2-neurturin)2008–2015Trial in peopleDid not work210919 Oct 20264
PDGF-BB into the ventricles2009–2015Trial in peopleMixed or early results11219 Oct 20264
Neurturin autopsies (Bartus)2011DiscoveryConfirmed and built on––19 Oct 20262
GM1 ganglioside2012Trial in peopleMixed or early results27719 Oct 20262
CDNF Phase 1/22017–2023Trial in peopleReplaced by a newer approach1/21719 Oct 20263
RET agonists: small-molecule GDNF mimics2017–2021Lab study (cells or animals)Still being studied––20 Oct 20263
Fosgonimeton (SHAPE)2022–2023Trial in peopleDid not work22819 Oct 20265
REGENERATE-PD AB-10052024–2028Trial in peopleResult due Aug 2028212718 Oct 20263

Also tagged with this lane

2 landmarks drawn in another lane but tagged with this one. Select a column heading to sort.
Striatal terminals are lost first2013DiscoveryStill being studied––19 Oct 20263
Nurr1 (NR4A2) activators2015–2024Lab study (cells or animals)Still being studied––20 Oct 20264

Built on work from

Led to work in

None.

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