Foundations
The lane
- Status
- Done. Settled. Later work builds on it.
- Verdict
- Lewy bodies and dopamine loss define what any cure must protect or restore.
- Family
- Trunk
- Landmarks
- 4 in this lane, 1 more tagged with it. Advanced 4
The verdict and status come from the project's branches.yaml and use research wording.
Landmarks in this lane
| Lewy bodies described; tied to the substantia nigra | 1912–1919 | Discovery | Confirmed and built on | – | – | 19 Oct 2026 | 2 |
| Carlsson: dopamine is a brain transmitter | 1957–1958 | Discovery | Confirmed and built on | – | – | 19 Oct 2026 | 3 |
| Dopamine is missing from the Parkinson's brain | 1960 | Discovery | Confirmed and built on | – | – | 19 Oct 2026 | 2 |
| Levodopa becomes standard treatment | 1961–1967 | Discovery | Confirmed and built on | – | – | 19 Oct 2026 | 4 |
Also tagged with this lane
| 6-OHDA model and first rat dopamine grafts | 1968–1979 | Research model | Confirmed and built on | – | – | 19 Oct 2026 | 5 |
Links with other lanes
Built on work from
None.
Led to work in
- Trial methods & regulation: 6 links
- Selective vulnerability: 5 links
- Synuclein misfolding & spread: 2 links
- Oxidative stress: 2 links
- Growth factors: 2 links
- Environment & lifestyle: 1 link
- Gene therapy & delivery: 1 link
- Cell replacement: 1 link
- Gut–brain origin: 1 link
- Biomarkers: 1 link
- Inflammation & immunity: 1 link