Parkinson's Cure Journey

Cell replacement

The lane

Status
Active. Trials are running and the idea is still being tested.
Verdict
Strongest branch: conditional approval in Japan; bemdaneprocel Phase 3 (exPDite-2) reads out ~2027; fetal and Spheramine grafts failed; does not stop the disease.
Family
Restoration
Landmarks
26 in this lane, 1 more tagged with it. Advanced 9 · Open 6 · Pending 6 · Superseded 1 · Dead end 4

The verdict and status come from the project's branches.yaml and use research wording.

Landmarks in this lane

26 landmarks drawn in this lane, oldest first. Select a column heading to sort.
6-OHDA model and first rat dopamine grafts1968–1979Research modelConfirmed and built on––19 Oct 20265
First fetal dopamine-cell transplants1987–1990Trial in peopleReplaced by a newer approach––19 Oct 20264
Freed: sham-controlled fetal grafts2001Trial in peopleDid not work24022 Oct 20266
Olanow: sham-controlled fetal grafts2003Trial in peopleDid not work23419 Oct 20264
iPSC reprogramming (Yamanaka)2006–2007Research toolConfirmed and built on––19 Oct 20264
Spheramine (STEPS)2008–2011Trial in peopleDid not work27119 Oct 20263
Serotonin neurons cause graft dyskinesias2010DiscoveryConfirmed and built on––19 Oct 20262
TRANSEURO fetal grafts2010–2026Trial in peopleDid not work–1122 Oct 20263
Stem cells to transplantable dopamine neurons2011Research toolConfirmed and built on––19 Oct 20263
Skin cells to dopamine neurons, no stem-cell stage2011Research toolStill being studied––19 Oct 20264
Lund's embryonic-stem-cell dopamine recipe2012–2017Research toolConfirmed and built on––19 Oct 20262
iPSC-derived neurons work in monkeys2017Lab study (cells or animals)Confirmed and built on––20 Oct 20262
Kyoto iPSC dopamine-cell trial2018–2025Trial in peoplePassed this stage2722 Oct 20264
First graft of a patient's own iPSC neurons2020Trial in peopleMixed or early results––19 Oct 20264
Turning astrocytes into neurons: a dispute2020–2023Lab study (cells or animals)Still being studied––20 Oct 20264
STEM-PD trial2023–2026Trial in peopleMixed or early results2822 Oct 20263
Aspen ASPIRO: patient-own-cell neurons2024–2026Trial in peopleResult due Mar 202721519 Oct 20265
NouvNeu001 (iRegene)2024–2026Trial in peopleMixed or early results23019 Oct 20264
Brigham and Women's autologous iPSC dopamine cells2024–2028Trial in peopleResult due Dec 202811219 Oct 20264
UC San Diego CT1-DAP001 donor iPSC cells2024–2028Trial in peopleResult due Dec 20271719 Oct 20263
Bemdaneprocel embryonic stem-cell dopamine neurons2025Trial in peoplePassed this stage––19 Oct 20264
exPDite-2 bemdaneprocel Phase 32025–2027Trial in peopleResult due Mar 2027310218 Oct 20262
Wave of Chinese iPSC dopamine-cell trials2025–2026Trial in peopleMixed or early results2–19 Oct 20265
RNDP-001 (Kenai) REPLACE2025–2027Trial in peopleResult due Sep 202721219 Oct 20266
Mass General autologous iPSC implant2025–2028Trial in peopleResult due Dec 20271819 Oct 20265
Japan conditionally approves Amchepry (iPS-cell dopamine precursors)2026Research infrastructureConfirmed and built on––22 Oct 20266

Also tagged with this lane

1 landmarks drawn in another lane but tagged with this one. Select a column heading to sort.
Lewy bodies in grafts: prion-like spread2008DiscoveryStill being studied––19 Oct 20263

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