Parkinson's Cure Journey

Synuclein misfolding & spread

The lane

Status
Active. Trials are running and the idea is still being tested.
Verdict
Cinpanemab and minzasolmin failed; prasinezumab Phase 3 PARAISO runs to 2029; exidavnemab and UB-312 have safety data only.
Family
Synuclein
Landmarks
31 in this lane, 3 more tagged with it. Advanced 11 · Open 13 · Pending 4 · Dead end 3

The verdict and status come from the project's branches.yaml and use research wording.

Landmarks in this lane

31 landmarks drawn in this lane, oldest first. Select a column heading to sort.
First Parkinson's gene: SNCA1997DiscoveryConfirmed and built on––19 Oct 20264
Alpha-synuclein is what Lewy bodies are made of1997DiscoveryConfirmed and built on––19 Oct 20262
Further SNCA point mutations1998–2013DiscoveryConfirmed and built on––19 Oct 20265
Drosophila synuclein model2000Research modelConfirmed and built on––19 Oct 20263
A53T alpha-synuclein mice2002Research modelConfirmed and built on––19 Oct 20265
Synuclein Ser129 phosphorylation2002DiscoveryStill being studied––19 Oct 20263
Braak staging: the disease spreads in order2003DiscoveryStill being studied––19 Oct 20262
Vaccinating mice against synuclein2005DiscoveryConfirmed and built on––19 Oct 20263
Lewy bodies in grafts: prion-like spread2008DiscoveryStill being studied––19 Oct 20263
Critiques of Braak staging2008–2009DiscoveryStill being studied––19 Oct 20263
Synuclein travels in vesicles2010DiscoveryStill being studied––19 Oct 20265
Fibril-seeding (PFF) models2011–2012Research modelConfirmed and built on––19 Oct 20264
Synuclein oligomers are toxic2011DiscoveryStill being studied––19 Oct 20264
9E4 antibody in mice (paper retracted 2024)2011Lab study (cells or animals)Did not hold up––19 Oct 20262
One injection of fibrils spreads pathology2012DiscoveryConfirmed and built on––19 Oct 20262
PD01A synuclein vaccine (AFFiRiS)2012–2020Trial in peoplePassed this stage13219 Oct 20263
Patient Lewy body extracts harm mice and monkeys2014DiscoveryConfirmed and built on––19 Oct 20263
Synuclein strains2015DiscoveryStill being studied––19 Oct 20263
LAG3 as a synuclein-fibril receptor2016–2021DiscoveryStill being studied––20 Oct 20264
Atomic structures of synuclein fibrils2018–2022DiscoveryConfirmed and built on––20 Oct 20264
Lewy bodies are full of lipids and organelles2019DiscoveryStill being studied––20 Oct 20263
Anle138b (emrusolmin)2019–2026Trial in peopleMixed or early results1–22 Oct 20263
SPARK: cinpanemab2021–2022Trial in peopleDid not work235722 Oct 20263
Prasinezumab: PASADENA and PADOVA2022–2026Trial in peopleMixed or early results2–22 Oct 20265
UB-312 synuclein vaccine2022–2025Trial in peopleMixed or early results12019 Oct 20262
ACI-7104 VacSYn Phase 22023–2028Trial in peopleResult due Jun 2028215019 Oct 20265
ORCHESTRA: minzasolmin2024Trial in peopleDid not work249622 Oct 20265
ML-designed synuclein aggregation inhibitors2024Lab study (cells or animals)Still being studied––20 Oct 20263
Exidavnemab (EXIST)2024–2026Trial in peopleResult due Dec 202623819 Oct 20265
PARAISO prasinezumab Phase 32025–2029Trial in peopleResult due Jun 2029390018 Oct 20261
PreCoDe: prasinezumab in GBA carriers2025–2030Trial in peopleResult due Dec 2030212022 Oct 20265

Also tagged with this lane

3 landmarks drawn in another lane but tagged with this one. Select a column heading to sort.
Chaperone-mediated autophagy2004DiscoveryStill being studied––19 Oct 20263
Synuclein travels gut to brain in rats2014DiscoveryStill being studied––19 Oct 20265
Gut-to-brain spread in mice2019DiscoveryStill being studied––20 Oct 20263

Built on work from

Led to work in

See this lane on the map · All lanes