Parkinson's Cure Journey

Models

The lane

Status
Enabler. Tools, methods and resources that the other lanes depend on.
Verdict
Patient-derived neurons and organoids not tied to one hypothesis.
Family
Enabler
Landmarks
8 in this lane, 11 more tagged with it. Advanced 6 · Open 2

The verdict and status come from the project's branches.yaml and use research wording.

Landmarks in this lane

8 landmarks drawn in this lane, oldest first. Select a column heading to sort.
Yeast synuclein models2003–2006Research modelConfirmed and built on––19 Oct 20264
Knockout mice keep their neurons2003–2007Research modelStill being studied––19 Oct 20264
Patient-derived dopamine neurons2011Research modelConfirmed and built on––19 Oct 20263
Isogenic patient stem-cell lines2011Research toolConfirmed and built on––19 Oct 20264
Midbrain organoids2016Research modelStill being studied––20 Oct 20262
FOUNDIN-PD dopamine-neuron atlas2021–2023Research infrastructureConfirmed and built on––19 Oct 20265
KOLF2.1J reference stem cell line2022Research toolConfirmed and built on––19 Oct 20264
iSCORE-PD cell collection2024–2026Research infrastructureConfirmed and built on––20 Oct 20262

Also tagged with this lane

11 landmarks drawn in another lane but tagged with this one. Select a column heading to sort.
6-OHDA model and first rat dopamine grafts1968–1979Research modelConfirmed and built on––19 Oct 20265
MPTP: a chemical that causes Parkinson's1983DiscoveryConfirmed and built on––19 Oct 20264
Rotenone reproduces Parkinson's features in rats2000Research modelConfirmed and built on––19 Oct 20263
Drosophila synuclein model2000Research modelConfirmed and built on––19 Oct 20263
A53T alpha-synuclein mice2002Research modelConfirmed and built on––19 Oct 20265
Virus-driven synuclein rat and marmoset models2002–2003Research modelConfirmed and built on––19 Oct 20264
iPSC reprogramming (Yamanaka)2006–2007Research toolConfirmed and built on––19 Oct 20264
PINK1 and parkin share a pathway (flies)2006Research modelConfirmed and built on––19 Oct 20263
MitoPark mouse2007Research modelStill being studied––19 Oct 20261
Fibril-seeding (PFF) models2011–2012Research modelConfirmed and built on––19 Oct 20264
Patient Lewy body extracts harm mice and monkeys2014DiscoveryConfirmed and built on––19 Oct 20263

Built on work from

Led to work in

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