Parkinson's Cure Journey

LRRK2

The lane

Status
Narrowed. Several attempts failed; work continues in a smaller group or with a different drug.
Verdict
Raised LRRK2 activity in ordinary Parkinson's justified LUMA, which failed; lung findings proved reversible; BEACON (carriers) and NEU-411 read out in 2027.
Family
Housekeeping
Landmarks
19 in this lane, 3 more tagged with it. Advanced 10 · Open 4 · Pending 2 · Superseded 1 · Dead end 2

The verdict and status come from the project's branches.yaml and use research wording.

Landmarks in this lane

19 landmarks drawn in this lane, oldest first. Select a column heading to sort.
The LRRK2 gene: the first gene-based drug target2004DiscoveryStill being studied––19 Oct 20260
LRRK2 G2385R and R1628P2006–2008DiscoveryConfirmed and built on––19 Oct 20263
How often LRRK2 G2019S carriers get Parkinson's2008DiscoveryConfirmed and built on––19 Oct 20263
VPS35 mutation and the retromer2011DiscoveryStill being studied––19 Oct 20263
RAB29 recruits and activates LRRK22013–2018DiscoveryConfirmed and built on––19 Oct 20264
LRRK2 inhibitor lung findings2015–2020DiscoveryConfirmed and built on––20 Oct 20263
LRRK2 phosphorylates Rab proteins2016DiscoveryConfirmed and built on––20 Oct 20264
LRRK2 and lysosome damage2018DiscoveryStill being studied––20 Oct 20264
LRRK2 overactive in idiopathic Parkinson's2018DiscoveryStill being studied––20 Oct 20262
PPM1H reverses LRRK2's Rab tags2019DiscoveryConfirmed and built on––19 Oct 20263
People with one broken LRRK2 copy are healthy2020DiscoveryConfirmed and built on––20 Oct 20265
Detailed 3D structures of LRRK22020–2021DiscoveryConfirmed and built on––20 Oct 20262
DNL151 (BIIB122) Phase 1 and 1b2021–2023Trial in peoplePassed this stage122019 Oct 20263
DNL201 Phase 1/1b2022Trial in peopleReplaced by a newer approach115019 Oct 20262
RAB32 Ser71Arg2024DiscoveryConfirmed and built on––20 Oct 20262
BEACON BIIB122 in LRRK2 carriers2024–2027Trial in peopleResult due Mar 202725019 Oct 20263
NEU-411 (NEULARK)2025–2027Trial in peopleResult due Dec 2027215018 Oct 20263
LRRK2 antisense BIIB0942026Trial in peopleDid not work18219 Oct 20262
BIIB122 / DNL151 (LUMA)2026Trial in peopleDid not work264819 Oct 20267

Also tagged with this lane

3 landmarks drawn in another lane but tagged with this one. Select a column heading to sort.
Target-engagement markers for LRRK2 drugs2010–2023Research toolConfirmed and built on––19 Oct 20265
IBD, anti-TNF drugs and LRRK22018DiscoveryStill being studied––20 Oct 20263
LRRK2 lowers GCase2019DiscoveryStill being studied––20 Oct 20263

Built on work from

Led to work in

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