Parkinson's Cure Journey

Gut–brain origin

The lane

Status
Open. The evidence points both ways; no therapy has been tested to the end.
Verdict
Mouse spread, registry data and body-first/brain-first subtypes are suggestive; faecal-transplant trials gave mixed results.
Family
Synuclein
Landmarks
14 in this lane, 3 more tagged with it. Advanced 2 · Open 9 · Superseded 1 · Dead end 2

The verdict and status come from the project's branches.yaml and use research wording.

Landmarks in this lane

14 landmarks drawn in this lane, oldest first. Select a column heading to sort.
Lewy bodies in the gut's nerve plexuses1988DiscoveryConfirmed and built on––19 Oct 20264
Constipation precedes Parkinson's2001DiscoveryConfirmed and built on––19 Oct 20264
Gut biopsies for synuclein2012–2016DiscoveryReplaced by a better idea––19 Oct 20263
Synuclein travels gut to brain in rats2014DiscoveryStill being studied––19 Oct 20265
Vagotomy and appendix studies2015–2018DiscoveryStill being studied––20 Oct 20263
Gut microbiome differs in Parkinson's2015–2022DiscoveryStill being studied––20 Oct 20263
Soroka faecal transplant pilot (Israel)2015–2020Trial in peopleMixed or early results21019 Oct 20263
Gut microbes and synuclein mice2016DiscoveryStill being studied––20 Oct 20262
ENT-01 (squalamine) KARMET2018–2022Trial in peopleMixed or early results215019 Oct 20264
Gut-to-brain spread in mice2019DiscoveryStill being studied––20 Oct 20263
Body-first vs brain-first Parkinson's2019–2020DiscoveryStill being studied––20 Oct 20264
Finnish faecal transplant trial2020–2024Trial in peopleDid not work24819 Oct 20264
EFFACE-PD faecal transplant (Warsaw)2022–2026Trial in peopleDid not work25918 Oct 20264
GUT-PARFECT faecal transplant2024Trial in peopleMixed or early results24619 Oct 20262

Also tagged with this lane

3 landmarks drawn in another lane but tagged with this one. Select a column heading to sort.
Braak staging: the disease spreads in order2003DiscoveryStill being studied––19 Oct 20262
IBD, anti-TNF drugs and LRRK22018DiscoveryStill being studied––20 Oct 20263
Gut infection in PINK1-knockout mice2019DiscoveryStill being studied––20 Oct 20263

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