Parkinson's Cure Journey

Biomarkers

The lane

Status
Enabler. Tools, methods and resources that the other lanes depend on.
Verdict
The seed test shows who has the disease, not how fast it progresses.
Family
Enabler
Landmarks
17 in this lane, 5 more tagged with it. Advanced 9 · Open 7 · Superseded 1

The verdict and status come from the project's branches.yaml and use research wording.

Landmarks in this lane

17 landmarks drawn in this lane, oldest first. Select a column heading to sort.
Fluorodopa PET1983Research toolConfirmed and built on––19 Oct 20263
REM sleep behaviour disorder becomes Parkinson's1996–2019DiscoveryConfirmed and built on––19 Oct 20262
DaTscan approved in the EU and US2000–2011Research toolConfirmed and built on––19 Oct 20263
Smell loss predicts Parkinson's2004–2008DiscoveryConfirmed and built on––19 Oct 20263
Neuromelanin MRI and nigrosome sign2006–2014Research toolStill being studied––19 Oct 20262
Free-water MRI2009–2017Research toolStill being studied––19 Oct 20264
Target-engagement markers for LRRK2 drugs2010–2023Research toolConfirmed and built on––19 Oct 20265
CSF total synuclein2011–2013DiscoveryReplaced by a better idea––19 Oct 20263
DAT scans qualified for trials2015–2018Research toolConfirmed and built on––20 Oct 20265
RT-QuIC and PMCA: first synuclein amplification2016–2020Research toolConfirmed and built on––20 Oct 20263
Neurofilament light2020Research toolStill being studied––20 Oct 20263
Blood seed amplification2022–2023Research toolStill being studied––20 Oct 20264
Seed amplification assay2023Research toolConfirmed and built on––20 Oct 20260
Synuclein PET tracers2023–2026Research toolStill being studied––20 Oct 20263
NSD-ISS and SynNeurGe definitions2024Research toolStill being studied––20 Oct 20263
Skin-biopsy synuclein (Syn-One)2024Research toolStill being studied––20 Oct 20263
FDA letter of support for the seed assay2024Research infrastructureConfirmed and built on––20 Oct 20262

Also tagged with this lane

5 landmarks drawn in another lane but tagged with this one. Select a column heading to sort.
CALM-PD β-CIT and REAL-PET2002–2003Trial in peopleReplaced by a newer approach–26819 Oct 20263
PPMI launches2010Research infrastructureConfirmed and built on––19 Oct 20263
Gut biopsies for synuclein2012–2016DiscoveryReplaced by a better idea––19 Oct 20263
LRRK2 phosphorylates Rab proteins2016DiscoveryConfirmed and built on––20 Oct 20264
Atomic structures of synuclein fibrils2018–2022DiscoveryConfirmed and built on––20 Oct 20264

Built on work from

Led to work in

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