Parkinson's Cure Journey

Inflammation & immunity

The lane

Status
Open. The evidence points both ways; no therapy has been tested to the end.
Verdict
Azathioprine (AZA-PD) failed; NLRP3 drugs are in patients (DAPA-PD due 2027); adalimumab is being tested for prevention in REM sleep disorder (PRISMS, 2029).
Family
Body
Landmarks
23 in this lane, 5 more tagged with it. Open 16 · Pending 4 · Dead end 3

The verdict and status come from the project's branches.yaml and use research wording.

Landmarks in this lane

23 landmarks drawn in this lane, oldest first. Select a column heading to sort.
Inflammation in the Parkinson's nigra1988DiscoveryStill being studied––19 Oct 20262
Ibuprofen and lower Parkinson's risk2003–2011DiscoveryStill being studied––19 Oct 20263
PET shows microglial activation in life2006Research toolStill being studied––19 Oct 20263
HLA-DR region GWAS signal2010DiscoveryStill being studied––19 Oct 20263
Sargramostim boosts regulatory T cells2015–2021Trial in peopleMixed or early results––19 Oct 20263
T cells recognise synuclein2017DiscoveryStill being studied––20 Oct 20263
Microglia can turn astrocytes toxic2017–2018DiscoveryStill being studied––19 Oct 20262
Parkin/PINK1–STING paper retracted2018DiscoveryDid not hold up––19 Oct 20262
NLRP3 inflammasome2018DiscoveryStill being studied––20 Oct 20265
IBD, anti-TNF drugs and LRRK22018DiscoveryStill being studied––20 Oct 20263
GRF6021 plasma fraction2018–2021Trial in peopleMixed or early results27919 Oct 20264
Gut infection in PINK1-knockout mice2019DiscoveryStill being studied––20 Oct 20263
AZA-PD azathioprine2020–2026Trial in peopleDid not work26619 Oct 20264
AKST4290 (TEAL)2020–2021Trial in peopleDid not work211019 Oct 20264
Synuclein T cells highest near diagnosis2020DiscoveryStill being studied––20 Oct 20263
Single-cell map of the Parkinson's midbrain2022DiscoveryStill being studied––20 Oct 20262
VTX3232 (NLRP3 inhibitor)2024–2025Trial in peopleMixed or early results21119 Oct 20266
VENT-02 (NLRP3)2025Trial in peopleMixed or early results12919 Oct 20263
BHV-8000 (TYK2/JAK1 inhibitor)2025–2027Trial in peopleResult due Aug 2027355019 Oct 20263
TB006 (galectin-3 antibody)2025–2026Trial in peopleResult due Nov 202626219 Oct 20263
Hydroxychloroquine (HCQ-PD)2025–2027Trial in peopleMixed or early results24022 Oct 20263
DAPA-PD (dapansutrile)2026–2027Trial in peopleResult due May 202723618 Oct 20263
RO7568282 (TARBELA-PD, NLRP3)2026–2028Trial in peopleResult due Dec 2028247419 Oct 20264

Also tagged with this lane

5 landmarks drawn in another lane but tagged with this one. Select a column heading to sort.
Mitochondrial-derived vesicles2012–2016DiscoveryStill being studied––19 Oct 20263
Gut microbes and synuclein mice2016DiscoveryStill being studied––20 Oct 20262
Simvastatin (PD STAT)2022Trial in peopleDid not work–23519 Oct 20262
NLY01 Phase 22023Trial in peopleDid not work225519 Oct 20265
PRISMS: adalimumab in RBD2026–2029Trial in peopleResult due Aug 2029210818 Oct 20263

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