Parkinson's Cure Journey

Selective vulnerability

The lane

Status
Open. The evidence points both ways; no therapy has been tested to the end.
Verdict
Calcium load, giant axons and a named subtype explain why; isradipine failed; Nurr1 activators are preclinical.
Family
Housekeeping
Landmarks
12 in this lane, 2 more tagged with it. Advanced 2 · Open 9 · Dead end 1

The verdict and status come from the project's branches.yaml and use research wording.

Landmarks in this lane

12 landmarks drawn in this lane, oldest first. Select a column heading to sort.
Calbindin dopamine neurons spared1990–1992DiscoveryStill being studied––19 Oct 20263
Nigral cell loss pattern differs from ageing1991DiscoveryConfirmed and built on––19 Oct 20263
Locus coeruleus loss alongside the nigra1992–2007DiscoveryStill being studied––19 Oct 20262
Nurr1 (NR4A2) discovery1997–2003DiscoveryConfirmed and built on––19 Oct 20262
Calcium channels and vulnerable neurons2007DiscoveryStill being studied––19 Oct 20262
VMAT2 and dopamine storage2007–2014Lab study (cells or animals)Still being studied––19 Oct 20264
Cytosolic dopamine, calcium and synuclein2009DiscoveryStill being studied––19 Oct 20263
The cost of a giant axon2013DiscoveryStill being studied––19 Oct 20263
Striatal terminals are lost first2013DiscoveryStill being studied––19 Oct 20263
Nurr1 (NR4A2) activators2015–2024Lab study (cells or animals)Still being studied––20 Oct 20264
Isradipine (STEADY-PD III)2019–2020Trial in peopleDid not work333619 Oct 20262
The most vulnerable dopamine neuron subtype2022DiscoveryStill being studied––20 Oct 20262

Also tagged with this lane

2 landmarks drawn in another lane but tagged with this one. Select a column heading to sort.
Iron and neuromelanin in the nigra1988–2019DiscoveryStill being studied––19 Oct 20264
Mitochondrial DNA deletions in nigral neurons2006DiscoveryStill being studied––19 Oct 20265

Built on work from

Led to work in

See this lane on the map · All lanes