Parkinson's Cure Journey

Trial methods & regulation

The lane

Status
Enabler. Tools, methods and resources that the other lanes depend on.
Verdict
Washout, delayed-start and imaging designs never proved slowing; prodromal criteria and REM sleep disorder cohorts now allow prevention trials (PRISMS, due 2029).
Family
Enabler
Landmarks
20 in this lane, 5 more tagged with it. Advanced 7 · Open 6 · Pending 2 · Superseded 3 · Dead end 2

The verdict and status come from the project's branches.yaml and use research wording.

Landmarks in this lane

20 landmarks drawn in this lane, oldest first. Select a column heading to sort.
Hoehn and Yahr staging scale1967Research toolReplaced by a better idea––19 Oct 20263
UK Brain Bank diagnostic criteria1992Research toolConfirmed and built on––19 Oct 20262
Placebo releases dopamine2001DiscoveryConfirmed and built on––19 Oct 20264
CALM-PD β-CIT and REAL-PET2002–2003Trial in peopleReplaced by a newer approach–26819 Oct 20263
ELLDOPA: levodopa and progression2004Trial in peopleReplaced by a newer approach336119 Oct 20263
NET-PD futility screens FS-1 and FS-22006–2007Trial in peoplePassed this stage2–19 Oct 20263
Vanderbilt early-DBS pilot2006–2020Trial in peopleMixed or early results–3019 Oct 20263
MDS-UPDRS2008Research toolConfirmed and built on––19 Oct 20264
EMA two-step rule for 'disease-modifying'2008–2025Research infrastructureStill being studied––19 Oct 20263
Linked Clinical Trials2013Research infrastructureConfirmed and built on––19 Oct 20262
EARLYSTIM early DBS2013Trial in peopleMixed or early results425119 Oct 20262
PROUD: pramipexole delayed start2013Trial in peopleDid not work353519 Oct 20263
MDS clinical diagnostic criteria2015Research infrastructureConfirmed and built on––20 Oct 20262
MDS prodromal criteria2015–2019Research toolConfirmed and built on––20 Oct 20262
LEAP: early vs delayed levodopa2019Trial in peopleDid not work344519 Oct 20262
Mobilise-D: sensor-measured walking2020Research toolStill being studied––20 Oct 20263
Idebenone in REM sleep behaviour disorder2020–2026Trial in peopleResult due Nov 202622822 Oct 20266
Australian Parkinson's Mission APM0012020–2026Trial in peopleMixed or early results213119 Oct 20264
EJS ACT-PD platform trial2025Research infrastructureStill being studied––20 Oct 20264
PRISMS: adalimumab in RBD2026–2029Trial in peopleResult due Aug 2029210818 Oct 20263

Also tagged with this lane

5 landmarks drawn in another lane but tagged with this one. Select a column heading to sort.
DATATOP: deprenyl1987–1993Trial in peopleReplaced by a newer approach–80019 Oct 20264
REM sleep behaviour disorder becomes Parkinson's1996–2019DiscoveryConfirmed and built on––19 Oct 20262
TEMPO: rasagiline delayed start2002–2009Trial in peopleReplaced by a newer approach340419 Oct 20262
ADAGIO: rasagiline2009Trial in peopleDid not work31,17619 Oct 20265
NAPS: prodromal synucleinopathy consortium2018–2028Research infrastructureStill being studied––20 Oct 20263

Built on work from

Led to work in

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