Parkinson's Cure Journey

Oxidative stress

The lane

Status
Pruned. Tested and abandoned for now.
Verdict
MAO-B inhibitors, urate and iron removal all failed to slow the disease.
Family
Housekeeping
Landmarks
13 in this lane, 2 more tagged with it. Open 3 · Pending 2 · Superseded 2 · Dead end 6

The verdict and status come from the project's branches.yaml and use research wording.

Landmarks in this lane

13 landmarks drawn in this lane, oldest first. Select a column heading to sort.
DATATOP: deprenyl1987–1993Trial in peopleReplaced by a newer approach–80019 Oct 20264
Iron and neuromelanin in the nigra1988–2019DiscoveryStill being studied––19 Oct 20264
Glutathione loss in the nigra1994DiscoveryStill being studied––19 Oct 20262
TEMPO: rasagiline delayed start2002–2009Trial in peopleReplaced by a newer approach340419 Oct 20262
Urate epidemiology2007–2008DiscoveryDid not hold up––19 Oct 20262
ADAGIO: rasagiline2009Trial in peopleDid not work31,17619 Oct 20265
Molecular hydrogen trials2013–2021Trial in peopleDid not work217819 Oct 20263
Mendelian randomisation: urate and BMI2014–2021DiscoveryDid not hold up––19 Oct 20261
N-acetylcysteine (Monti)2014–2027Trial in peopleResult due Jan 202725022 Oct 20264
Intranasal glutathione, Phase IIb2015–2017Trial in peopleMixed or early results24519 Oct 20262
SURE-PD3: inosine2021Trial in peopleDid not work329819 Oct 20262
FAIRPARK-II: deferiprone2022Trial in peopleDid not work237219 Oct 20261
NOSE-PD: nasal insulin plus glutathione2022–2027Trial in peopleResult due Nov 202725618 Oct 20263

Also tagged with this lane

2 landmarks drawn in another lane but tagged with this one. Select a column heading to sort.
Ferroptosis in dopamine neurons2012–2016DiscoveryStill being studied––19 Oct 20264
Dopamine oxidation damages the lysosome2017DiscoveryStill being studied––20 Oct 20263

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